Hogkin's lymphoma, also known as Hodgkin's disease, is a type of lymphoma first described by Thomas Hodgkin in 1832. Hodgkin's lymphoma is characterized clinically by the orderly spread of disease from one lymph node group to another and by the development of systemic symptoms with advanced disease. Pathologically, the disease is characterized by the presence of Reed-Sternberg cells. Hodgkin's lymphoma was one of the first cancers to be cured by radiation. Later it was one of the first to be cured by combination chemotherapy. The cure rate is about 93%, making it one of the most curable forms of cancer—if it is detected in the early stages. Later-stage cancers show a significantly worse prognosis. The Handbook of Cancer Chemotherapy, Sixth Edition states that "the potential for cure should not lead clinicians and patients to lose sight of the fact that [Hodgkin's lymphoma] is a malignancy and that approximately 20% to 25% of patients...die of the disease."