Carpal tunnel synrome (CTS) or median neuropathy at the wrist is a medical condition in which the median nerve is compressed at the wrist, leading to pain, paresthesias, and muscle weakness in the forearm and hand. A form of compressive neuropathy, CTS is more common in women than it is in men and has a peak incidence around age 42, though it can occur at any age. The lifetime risk for CTS is around 10% of the adult population..